产品简介

每粒Alpha Lipoic Acid300提供300毫克α- 硫辛酸。硫辛酸是一种既参与能量代谢又具有抗氧化活性的功能成分。

硫辛酸的营养功能 

α-硫辛酸是存在于线粒体内的辅酶，具有众多的生理功能[9]，如今已被研究确认的功能包括：

①作为辅酶，参与蛋白质、碳水化合物和脂肪代谢，可以促线粒体内能量生成[1]。 

②硫辛酸兼具水溶性和脂溶性，还可以活化体内其他抗氧化物，如维生素C、维生素E和谷胱甘肽，因此硫辛酸被称为“万能的抗氧化剂”。 

③硫辛酸可以提高胰岛素敏感性，促进血糖代谢，对抗糖基化，预防糖尿病神经病变[2~5]。  

④硫辛酸可辅助用于肝脏疾病，如酒精肝、脂肪肝、肝硬化[6]。  

⑤硫辛酸不仅可以降低重金属的细胞损伤作用，还可以促进体内重金属排泄，尤其对砷具有良好的螯合效果，可以作为有效的砷解毒剂[7]。  

⑥硫辛酸对大脑神经有一定的保护作用，可预防衰老引起的认知功能退化，如阿尔茨海默病[8]。

建议用量 

推荐每天1-2粒，或按营养专家的建议。

参考文献

[1]Pershadsingh HA. Alpha-lipoic acid: physiologic mechanisms and  indications for the treatment of metabolic syndrome. Expert Opin Investig  Drugs. 2007 Mar;16(3):291- 302 [PMID: 17302524].  

[2]Sola S, et al. Irbesartan and lipoic acid improve endothelial function  and reduce markers of inflammation in the metabolic syndrome: results of  the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study.  Circulation 2005;111:343-48. 

[3]Lee, WJ, Song KH, Koh EH, Won JC, Kim HS, Park HS, Kim MS, Kim SW, Lee  KU, Park JY. Alpha-lipoic acid increases insulin sensitivity by activating AMPK  in skeletal muscle. Biochem Biophys Res Commun 2005; 332: 885-891.  

[4]Ruderman NB, Saha AK, Kraegen EW. Minireview: malonyl CoA, AMPactivated protein kinase, and adiposity. Endocrinology 2003;144: 5166-5171. 

[5]Jacob S, Ruus P, Hermann R, et al. Oral administration of RAC-alpha-lipoic  acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a  placebocontrolled pilot trial. Free Radic Biol Med 1999; Aug 27(3- 4):309-14.

[6]Bustamante J, Lodge JK, Marcocci L, Tritschler HJ, Packer L, Rihn BH. Alpha-lipoic acid in liver metabolism and disease. Free Radic Biol Med. 1998 Apr;24(6):1023-39. doi: 10.1016/s0891-5849(97)00371-7. PMID: 9607614.

[7]Bjørklund G, Aaseth J, Crisponi G, Rahman MM, Chirumbolo S. Insights on alpha lipoic and dihydrolipoic acids as promising scavengers of oxidative stress and possible chelators in mercury toxicology. J Inorg Biochem. 2019 Jun;195:111-119. doi: 10.1016/j.jinorgbio.2019.03.019. Epub 2019 Mar 23. PMID: 30939378.

[8]Farr SA, Price TO, Banks WA, Ercal N, Morley JE. Effect of alpha-lipoic acid on memory, oxidation, and lifespan in SAMP8 mice. J Alzheimers Dis. 2012;32(2):447-55. doi: 10.3233/JAD-2012-120130. PMID: 22785389.

[9]Tripathi AK, Ray AK, Mishra SK, Bishen SM, Mishra H, Khurana A. Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention. Rev Bras Farmacogn. 2023;33(2):272-287. doi: 10.1007/s43450-023-00370-1. Epub 2023 Feb 7. PMID: 36778891; PMCID: PMC9904877.