突破：我的科学人生 卡塔林·考里科 2023年诺贝尔诺贝尔生理学或医学奖得主 英文原版 Breaking Through My Life in Science

基本信息

Publisher ? : ? Crown (October 10, 2023)

Language ? : ? English

Hardcover ? : ? 336 pages

ISBN-10 ? : ? 0593443160

ISBN-13 ? : ? 978-0593443163

Dimensions ? : ? 5.75 x 1.09 x 8.56 inches

页面参数仅供参考，具体以实物为准

书籍简介

卡塔琳-卡里科（Katalin Karikó）经历了一段不寻常的旅程。卡里科是战后共产主义匈牙利一个屠夫的女儿，在没有自来水的土坯房里长大，家里自己种蔬菜。她看到了周围大自然的神奇，决心成为一名科学家。这种决心终于把她带到了美国。1985 年，她带着缝在幼儿泰迪熊里的 1200 美元和重塑医学的梦想来到美国，成为一名博士后研究员。

卡里科默默无闻地工作，在没有窗户的实验室里与蟑螂搏斗，面对上司和同事的嘲笑甚至驱逐威胁。当有名的研究机构越来越多地将科学与金钱混为一谈时，她却不以为然。尽管遭遇挫折，但她从未动摇过自己的信念：一种名为信使 RNA 的短暂且不受重视的分子可以改变世界。卡里科相信，总有一天，mRNA 会把普通细胞变成能够按需生产药物的微小工厂。为了这个梦想，她几乎牺牲了一切，但她所面临的障碍只会激励她，后来她成功了。

卡里科对 mRNA 长达三十年的研究取得了惊人的成就：疫苗保护了数百万人免受 COVID-19 可怕后果的侵袭。这些疫苗只是 mRNA 潜力的开始。如今，医学界正翘首以待更多的 mRNA 疫苗--用于流感、艾滋病和其他新出现的传染病。

突破》不仅仅是一位非凡女性的故事。它是对封闭思想的控诉，也是一位女性在默默无闻中付出艰辛努力的见证--她知道自己可能永远不会被这个以声望、权力和特权为导向的文化所认可--因为她相信自己的工作能够拯救生命。

Katalin Karikó has had an unlikely journey. The daughter of a butcher in postwar communist Hungary, Karikó grew up in an adobe home that lacked running water, and her family grew their own vegetables. She saw the wonders of nature all around her and was determined to become a scientist. That determination eventually brought her to the United States, where she arrived as a postdoctoral fellow in 1985 with $1,200 sewn into her toddler’s teddy bear and a dream to remake medicine. 

Karikó worked in obscurity, battled cockroaches in a windowless lab, and faced outright derision and even deportation threats from her bosses and colleagues. She balked as prestigious research institutions increasingly conflated science and money. Despite setbacks, she never wavered in her belief that an ephemeral and underappreciated molecule called messenger RNA could change the world. Karikó believed that someday mRNA would transform ordinary cells into tiny factories capable of producing their own medicines on demand. She sacrificed nearly everything for this dream, but the obstacles she faced only motivated her, and eventually she succeeded.

Karikó’s three-decade-long investigation into mRNA would lead to a staggering achievement: vaccines that protected millions of people from the most dire consequences of COVID-19. These vaccines are just the beginning of mRNA’s potential. Today, the medical community eagerly awaits more mRNA vaccines—for the flu, HIV, and other emerging infectious diseases.

Breaking Through isn’t just the story of an extraordinary woman. It’s an indictment of closed-minded thinking and a testament to one woman’s commitment to laboring intensely in obscurity—knowing she might never be recognized in a culture that is driven by prestige, power, and privilege—because she believed her work would save lives.

作者简介

卡塔琳-卡里科（Katalin Karikó）博士是美籍匈牙利生化学家，专门研究 RNA 介导的机制。她是宾夕法尼亚大学神经外科的兼职教授，她的研究对辉瑞生物技术公司和 Moderna mRNA 疫苗的开发起到了奠基作用。

Katalin Karikó, PhD, is a Hungarian American biochemist who specializes in RNA-mediated mechanisms. She is an adjunct professor of neurosurgery at the University of Pennsylvania, and her research was foundational in the development of the Pfizer-BioNTech and Moderna mRNA vaccines.