产品简介

佛手柑提取物胶囊含有一系列强大而独特的佛手柑多酚组分，许多临床试验表明，这些独特的多酚对维持胆固醇平衡和心脏健康有益。[1-13]

营养说明  

提供38%佛手柑多酚组分®BPF，由新橙皮苷、柚皮苷、新北美圣草苷、布鲁西定组成。这些独特的多酚对维持胆固醇平衡和心脏健康有益。[1-13]

在一项安慰剂对照临床试验中，77名患者分为四个治疗组，1000mg佛手柑多酚有助于维持所有血脂标志物（HDL、LDL、TC、TRI）的健康水平。此外，该临床试验还表明，佛手柑多酚组分激活了炎症平衡酶AKT，并减少了中性粒细胞中丙二醛的产生。[1]

对80名患者进行的另一项临床试验显示，1500毫克佛手柑多酚维持了LDL-C的正常水平，并支持颈动脉中层的正常厚度。[2]

在一项涉及238名患者的安慰剂对照研究中，1000毫克的佛手柑多酚维持健康的胆固醇水平，并且表现优于接受传统疗法的组。[3]

其他几项最近发表的安慰剂对照临床试验还证明，佛手柑多酚可以帮助维持许多其他心脏代谢健康参数，包括健康水平的空腹血糖、瘦素、正常的炎症平衡、抗氧化潜力和COQ-10水平。[4-13]

推荐人群 

佛手柑提取物胶囊推荐高胆固醇或其他动脉硬化风险人群选择。

*UGN产品符合FDA和美国联邦贸易委员会关于营养补充剂产品相关疾病声明的监管要求，产品不用于预防、诊断和治疗任何疾病。如患有任何疾病，请咨询专业人员。

建议用量 

成人每天服用 2 粒，或按专业人员的指导服用。

[1]liozzi M, Walker R, Muscoli S, Vitale C, Gratteri S, Carresi C, Musolino V, Russo V, Janda E and Ragusa S. Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia. International journal of cardiology. 2013;170:140-145.

[2] Toth PP, Patti AM, Nikolic D, Giglio RV, Castellino G, Biancucci T, Geraci F, David S, Montalto G and Rizvi A. Bergamot Reduces Plasma Lipids, Atherogenic Small Dense LDL, and Subclinical Atherosclerosis in Subjects with Moderate Hypercholesterolemia: A 6 Months Prospective Study. Frontiers in pharmacology. 2015;6.

[3]Mollace V, Sacco I, Janda E, Malara C, Ventrice D, Colica C, Visalli V, Muscoli S, Ragusa S and Muscoli C. Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies. Fitoterapia. 2011;82:309-316.

[4]Di Donna L, Iacopetta D, Cappello AR, Gallucci G, Martello E, Fiorillo M, Dolce V and Sindona G. Hypocholesterolaemic activity of 3-hydroxy-3-methyl-glutaryl flavanones enriched fraction from bergamot fruit (Citrus bergamia):“In vivo” studies. Journal of Functional Foods. 2014;7:558-568.

[5]Campolongo G, Riccioni CV, Raparelli V, Spoletini I, Marazzi G, Vitale C and Volterrani M. The combination of nutraceutical and simvastatin enhances the effect of simvastatin alone in normalising lipid profile without side effects in patients with ischemic heart disease. IJC Metabolic & Endocrine. 2016;11:3-6.

[6] Cappello A, Dolce V, Iacopetta D, Martello M, Fiorillo M,Curcio R, Muto L and Dhanyalayam D. Bergamot (Citrus bergamia Risso) Flavonoids and Their Potential Benefits in Human Hyperlipidemia and Atherosclerosis: an Overview. Mini reviews in medicinal chemistry. 2015.

[7]Giglio RV, Patti AM, Nikolic D, Volti GL, Al-Rasadi K, KatsikiN, Mikhailidis DP, Montalto G, Ivanova E and Orekhov AN. The effect of bergamot on dyslipidemia. Phytomedicine. 2015.

[8]Janda E, Lascala A, Martino C, Ragusa S, Nucera S, Walker R, Gratteri S and Mollace V. Molecular mechanisms of lipid and glucose-lowering activities of bergamot flavonoids. PharmaNutrition. 2016.

[9]Mollace V, Ragusa S, Sacco I, Muscoli C, Sculco F, Visalli V, Palma E, Muscoli S, Mondello L and Dugo P. The protective effect of bergamot oil extract on lecitine-like oxyLDL receptor-1 expression in balloon injury-related neointima formation. Journal of cardiovascular pharmacology and therapeutics. 2008;13:120-129.

[10]Risitano R, Currò M, Cirmi S, Ferlazzo N, Campiglia P, Caccamo D, Ientile R and Navarra M. Flavonoid fraction of Bergamot juice reduces LPS-induced inflammatory response through SIRT1-mediated NF-κB inhibition in THP-1 monocytes. PLoS One. 2014;9:e107431.

[11]Trombetta D, Cimino F, Cristani M, Mandalari G, Saija A, Ginestra G, Speciale A, Chirafisi J, Bisignano G and Waldron K. In vitro protective effects of two extracts from bergamot peels on human endothelial cells exposed to tumor necrosis factor-α (TNF-α). Journal of agricultural and food chemistry. 2010;58:8430-8436.

[12]Benson J. ALTERNATIVE MEDICINE CABINET: Bergamot. Alternative Medicine. 2015:49.

[13]Capomolla AS, Janda E, Paone S, et al. Atherogenic Index Reduction and Weight Loss in Metabolic Syndrome Patients Treated with A Novel Pectin-Enriched Formulation of Bergamot Polyphenols. Nutrients. 2019;11(6):1271. Published 2019 Jun 4. doi:10.3390/nu11061271.