定价： 498

版次：1

包装：精装

开本：16开

用纸：胶版纸

Chronic rhinosinusitis (CRS) is a common disease, causing symptoms and  impacting on quality of life of patients. Since 1980s, we have learned to  understand CRS as a physical problem, a problem of drainage and ventilation, of ciliary activity to clean the sinuses. The proposed surgical approach  by Messerklinger and Stammberger as well as Wigand and Hosemann incorporated these ideas, and many authors and guidelines adopted it. This  approach was right in great parts, but did not yet appreciate the fact that sinus  disease is so variable, and immunology does play a significant role much  more than anticipated at that time point. It is clear today that the Messerklinger  technique does not work in severe type 2 nasal polyposis, and one needs a  better understanding of the immunology of the disease—and consequently  the recognition of endotypes—to be able to address the diversity of CRS  disease and tailor management and therapy to a variety of very different disease endotypes. Our understanding of the pathophysiology of CRS has developed from a physical problem to a mucosal problem.

本书目录

1 Introduction 

Claus Bachert and Luo Zhang

2 Epidemiology

Xiangdong Wang, Ming Zheng, and Luo Zhang

3 Quality of Life and Psychological Burden

Eduardo Lehrer, Mauricio López-Chacón, Isam Alobid, 

and Joaquim Mullol

4 Genetics and Epigenetics 

Jingyun Li, Luo Zhang, and Yuan Zhang

5 Involvement of the Immune System in Airways Disease

Wei Wang and Ying Sun

6 T Cells and Group 2 Innate Lymphoid Cells 2

Atsushi Kato and Robert P. Schleimer

7 B Cells and Plasma Cells 

Siobhan Ward, Zeynep Celebi Sözener, and Mübeccel Akdis

8 Eosinophils 

Elien Gevaert

9 Neutrophils 

Elien Gevaert

10 Remodeling Features

Lili Shi and Zheng Liu

11 Nasal Mucociliary Clearance 

Jian Jiao and Luo Zhang

12 Sinonasal Epithelium

Michael Soyka and Cezmi A. Akdis

13 Microbiology 

Mahboobeh Mahdavinia and Robert P. Schleimer

14 Staphylococcus aureus and Its Proteins

Goran Abdurrahman and Barbara M. Bröker

15 Viruses

Feng Lan and Luo Zhang

16 Environmental and Allergic Triggers 

17 Dysfunctional Immune Regulatory System

Jinmei Xue, Pingchang Yang, and Changqing Zhao

18 Chronic Rhinosinusitis with and Without Nasal Polyps

Bradley F. Marple

19 Allergic Fungal Sinusitis 

Fenghong Chen, Matthew W. Ryan, and Bradley F. Marple

20 Type 2 Immune Reactions and Consequences 

Claus Bachert

21 Regional Difference

Kun Du and Xiangdong Wang

22 Multimorbidities 

David Bedoya, Cristóbal Langdon, Isam Alobid, José Antonio 

Castillo, and Joaquim Mullol

23 Clinical Diagnosis and Phenotypes 

Kevin Hur and Robert C. Kern

24 Imaging the Anatomic Landmarks for Safe FESS

Simion James Zinreich and Sachin K. Gujar

25 Olfactory Function Assessment 

Meritxell Valls-Mateus, Franklin Mariño-Sánchez, Isam 

Alobid, Concepció Marin, and Joaquim Mullol

26 Local and Systemic Biomarkers

Nan Zhang

27 Benign Tumors of the Nose and Sinuses

Manuel Bernal-Sprekelsen

28 Sinonasal Inverted Papilloma

Chengshuo Wang, Siyuan Ma, and Luo Zhang

29 Malignant Tumors of the Nose and Sinuses 

Manuel Bernal-Sprekelsen and Isam Alobid

30 Pediatric Chronic Rhinosinusitis: View from Europe

Thibaut van Zele

31 Pediatric Chronic Sinusitis: View from China 

Jingying Ma and Bing Zhou

Contents

32 Wegener’s Granulomatosis 

Jichao Sha and Dongdong Zhu

33 IgG4-Related Disorders 

Yingshi Piao

34 Eosinophilic Granulomatosis with Polyangiitis 

Yujie Cao and Huabin Li

35 Oral Corticosteroids

Chengshuo Wang, Yifan Meng, and Luo Zhang

36 Nasal Spray Corticosteroids

Yujie Cao, Huabin Li, and Dehui Wang

37 Nebulization Corticosteroids

Chengshuo Wang, Yifan Meng, and Luo Zhang

38 Steroid-Eluting Stent Placement

Chengshuo Wang, Longgang Yu, and Luo Zhang

39 Steroid Infiltrated Packing Materials

Yueqi Sun and Jianbo Shi

40 Corticosteroids Resistance

Yujie Cao, Dehui Wang, and Huabin Li

41 Leukotriene Receptor Antagonists 

Rui Zheng, Tian Yuan, and Qintai Yang

42 Antihistamine

Hongfei Lou, Yanran Huang, and Luo Zhang

43 Antibiotics

Dawei Wu and Yongxiang Wei

44 Decongestant and Nasal Irrigation

Xiaoping Lai and Gehua Zhang

45 Probiotics, Bacterial Lysates, and Proton Pump Inhibitors

Luping Zhu and Lei Cheng

46 Impact of Endotyping on the Indication for Surgery 

Claus Bachert

47 Surgical Procedures

Ashleigh Halderman and Bradley F. Marple

48 Reboot Surgery

49 Complications of Endoscopic Sinus Surgery

Yi Dong and Bing Zhou

50 Peri-operative Management

Jian Li and Weiping Wen

Contents51 Surgery Outcome and Predictors

Fenghong Chen and Jianbo Shi

52 Biologics in Chronic Rhinosinusitis with Nasal Polyps 

Claus Bachert

53 Integrated Care Pathways 

Claus Bachert and Nan Zhang

54 Unmet Needs 

Luo Zhang and Claus Bachert

Correction to: Staphylococcus aureus and Its Proteins

Goran Abdurrahman and Barbara M. Bröker

Index