《Pharmaceutical Dosage Form and Technology（药物剂型与工艺）》通过介绍药物剂型和药物载体系统的处方、制备工艺过程、科学原理和临床应用特点等，使读者初步了解药物制剂与工艺的基本原理、剂型设计、处方筛选以及不同药物剂型的临床应用等知识，还可以对一些制剂的新、zui前沿研究成果有所了解。本书共10章：第1章是基础知识介绍；第2章和第3章是固体药物制剂；第4章和第5章分别是肺部用药系统和透皮药物运载系统；第6章和第7章分别是液体制剂和无菌制剂；第8章是口服载药系统和该领域的新研究成果；第9章是栓剂；第10章是有关儿童患者和老年患者临床用药注意事项。本书内容精炼、通俗易懂、英语语法准确，贴合实际教学需求，有助于提高学生专业英语水平。
本书可以作为药学类专业本科生或研究生药物制剂与工艺学及相关课程的教材，也可以作为药学相关领域科研人员的参考书。

张奇，北京理工大学化工与环境学院制药工程系，副教授，2013年9月—2013年10月，在英国School of Pharmacy, University College of London（UCL）药学院学习，北京理工大学全英文课程建设培训项目。
2010年10月—2011年11月，在英国School of Pharmacy, University of London 药学院，访问学者工作。
1997年9月-2000年7月，沈阳药科大学，药学专业学习，获博士学位。
2001年1月-2003年5月，清华大学化学系，博士后工作。
2003年5-今，北京理工大学化工与环境学院工作，副教授职称。
教学工作：承担过或正在承担本科生《制剂工程学》、本科生《天然药物化学》、硕士研究生全英文课程《药物制剂与工艺》、《文献检索与科技论文撰写》等课程。
研究方向与专长：分子肽类化合物的合成修饰及应用研究。生物体内靶向制剂的研究与应用研究，包括脂质体、纳米粒、高分子聚合物等作为载体的制剂研究。传统缓控释制剂、速释制剂的研究及应用。蛋白类化合物的分离纯化及结构鉴定。具体科研项目如下。
1. 鱼腥草素-PEG衍生物研究。（国家科技重大专项子课题，项目负责人）
2. 娜芬沙坦缓释片研究。（国家科技重大专项子课题，项目负责人）
3. 五环十一烷的绿色合成方法。（化学电源与绿色催化北京市重点实验室2014年度开放课题，项目负责人）
4. 长循环纳米粒的研究。（中国博士后基金，项目负责人）
5. 制药工程专业综合改革（本科）。（2016年教育部教育教学改革专项项目，项目负责人）
6. 北京理工大学与企业联合培养工程硕士基地建设项目。（2016全国工程专业学位研究生教育指导委员会教改项目，项目负责人）

Chapter 1 Introduction 1
1.1 Drugs and diseases 1
1.1.1 Treatment of diseases 1
1.1.2 Drug substances and medicines 1
1.1.3 The history of drugs 2
1.1.4 The drug-target interaction 3
1.2 About pharmacy 5
1.2.1 Pharmaceutical sciences 5
1.2.2 Pharmaceutics 5
1.2.3 Dosage forms and drug delivery systems 6
1.2.4 Categories of DDS 9
1.3 The standardization of medicine 11
1.3.1 Why medicine needs standard 11
1.3.2 Pharmacopeia 12
1.4 Clinical using medicine 12
1.4.1 Brand medicine and generic medicine 12
1.4.2 Prescription medicine and over-the-counter medicine 13
1.4.3 Prescription 13
1.4.4 Drug-drug interaction 14
1.4.5 Drug-food interaction 14
References 16

Chapter 2 Solid dosage forms I 17
2.1 Introduction 17
2.2 Powder 18
2.3 Granules 20
2.3.1 Preparation of granules 22
2.3.2 Granulation methods and equipments 22
2.3.3 Quality control of granules 31
References 33

Chapter 3 Solid dosage forms II 34
3.1 Capsules 34
3.1.1 Hard gelatin capsules 34
3.1.2 Soft capsules 36
3.2 Tablets 37
3.2.1 Excipients of tablets 39
3.2.2 Manufacture of tablets 40
3.2.3 Film coating 42
3.2.4 Quality control of tablets 53
3.2.5 Packaging and storing of tablets 58
References 59

Chapter 4 Pulmonary drug delivery system 60
4.1 Introduction 60
4.1.1 Anatomy of lungs 60
4.1.2 Advantages of pulmonary drug delivery 61
4.1.3 Mechanisms of particle deposition in the lung 62
4.2 Pulmonary drug delivery devices 62
4.2.1 Nebulizers 63
4.2.2 pMDIs 64
4.2.3 DPIs 64
4.2.4 Soft mist inhaler 65
4.3 Factors governing aerosol deposition and targeting in the lung 66
4.3.1 Aerodynamic diameter and size distribution 66
4.3.2 Airflow rate 66
4.3.3 Particle shape 67
4.3.4 Particle density 67
4.3.5 Surface roughness 67
4.4 Clinical application of pulmonary drug delivery systems 68
4.5 Perspectives of pulmonary drug delivery 69
References 70

Chapter 5 Transdermal drug delivery system 73
5.1 Introduction 73
5.2 Skin structure and the major obstacles of transdermal permeation 74
5.3 Major transdermal routes 75
5.3.1 Appendageal routes 75
5.3.2 Transcellular routes 75
5.3.3 Intercellular routes 75
5.4 Chemical penetration enhancers 76
5.4.1 Natural chemical penetration enhancers 76
5.4.2 Synthetic chemical penetration enhancers 77
5.4.3 Combination of penetration enhancers 82
5.5 Physical techniques to improve transdermal delivery 83
5.5.1 Microneedle 83
5.5.2 Laser 84
5.5.3 Iontophoresis 86
5.5.4 Sonophoresis 87
5.5.5 Electroporation 89
5.5.6 Magnetophoresis 90
5.5.7 Microwave 90
5.6 Transdermal formulations 91
5.6.1 Liposome 91
5.6.2 Cubic phase 91
5.6.3 Microemulsion 91
5.6.4 Hydrogel 91
5.6.5 Transfersome 92
5.7 Device-assisted or wearable transdermal delivery systems 92
5.7.1 Development stages 92
5.7.2 Device 93
5.7.3 Application 94
5.7.4 Prospect 94
References 94

Chapter 6 Liquid dosage forms 101
6.1 Introductions 101
6.1.1 Solubilities 101
6.1.2 Solvents 102
6.1.3 Enhancements 103
6.2 Syrups 103
6.3 Elixirs 104
6.4 Suspensions 105
6.4.1 Sedimentation of particles in suspension 105
6.4.2 Preparation of suspensions 107
6.4.3 Colloidal dispersions 108
6.5 Emulsions 109
6.5.1 Pharmaceutical emulsions 110
6.5.2 Emulsion formation theory 111
6.5.3 Emulsion identification 112
6.5.4 Emulsion preparation 112
6.5.5 The HLB system 116
6.5.6 Emulsion stability 117
6.5.7 Nanoemulsions 120
6.6 Creams 121
6.7 Gels and magmas 122
References 123

Chapter 7 Sterilized preparations 124
7.1 Principles of sterilization 124
7.1.1 Introduction 124
7.1.2 Sterilization parameters 124
7.1.3 Principles of sterilization processes 125
7.1.4 Gaseous sterilization 127
7.1.5 Radiation sterilization 128
7.1.6 Filtration sterilization 129
7.1.7 High-level disinfection 129
7.2 Parenteral 130
7.2.1 Introduction 130
7.2.2 Injections 130
7.2.3 Large-volume parenterals 131
7.3 Biologics 131
7.3.1 Introduction 131
7.3.2 Types of immunity 132
7.3.3 Production of biologics 132
7.4 Ophthalmic solution and suspensions 133
7.4.1 Introduction 133
7.4.2 Pharmaceutical requirements 134
References 136

Chapter 8 Modified-release oral drug delivery 138
8.1 Introduction of modified-release oral drug delivery 138
8.1.1 Sustained-release preparation 138
8.1.2 Controlled-release preparation 138
8.1.3 Delayed-release preparation 138
8.2 Theories of extended-release oral drug delivery 139
8.2.1 Theory of dissolution-controlled 139
8.2.2 Theory of diffusion-controlled 140
8.2.3 Combination of erosion and diffusion theory 141
8.2.4 Osmotic pressure theory 142
8.2.5 Ion exchange theory 143
8.3 Design of extended-release oral drug delivery systems 144
8.3.1 Properties of drugs 144
8.3.2 Design requirements 147
8.4 Quality assessment 149
8.4.1 In vitro assessment 149
8.4.2 In vivo assessment 150
8.4.3 In vitro correlation 150
8.5 Application of extended-release oral drug delivery systems 154
8.6 Oral chronopharmacologic and oral site-specific drug delivery system 160
8.6.1 Overview 160
8.6.2 Theories 161
8.6.3 Brief introductions 163
8.6.4 Applications 166
References 171

Chapter 9 Suppositories 173
9.1 Introduction 173
9.2 Suppository bases 174
9.2.1 Fatty or oleaginous bases 174
9.2.2 Water-soluble or water-miscible bases 174
9.3 Preparation of suppositories 175
9.3.1 Manufacturing procedure 175
9.3.2 Displacement value 176
9.3.3 Quality control 177
9.3.4 Examples 177
9.4 Packing and storage 178
9.5 Special types of suppositories 178
References 179

Chapter 10 Paediatric and geriatric drug developent 180
10.1 Introduction 180
10.2 Physiological changes 180
10.3 Excipient safety 181
10.4 Taste 183
10.5 Formulation choices 184
10.5.1 Tablets 184
10.5.2 Liquids 185
10.5.3 Multiparticulates 186
10.5.4 Dispersible and orally dispersible formulations 186
10.5.5 Chewable tablets 187
References 188

Indexes 190

无