产品简介

Thyroid Nutrition含有甲状腺健康和激素合成所必需的碘、酪氨酸、维生素（VA、B2）、矿物质（锌、硒、锰）、植物提取物。

营养成分简介 

压力和某些营养的缺乏会影响甲状腺细胞代谢及甲状腺激素的正常合成。Thyroid Nutrition通过缓解肾上腺压力以及补充甲状腺所需的必需营养发挥甲状腺保健作用。

作为脱碘酶的辅酶，硒可以促进体内T4向T3转化，此外硒还被证明可以降低甲状腺相关抗体水平[3]，对缓解桥本氏甲状腺炎有帮助。一项对于6100多名受试者进行的横断面观察研究发现，硒缺乏地区人群甲状腺疾病患病率增加[4]。

作为重要的辅酶，锌在调节甲状腺激素合成和代谢方面（包括T4到T3的转化）发挥着重要作用[5]。一项针对甲减女性的随机双盲对照试验表明，无论是单独或与硒一起服用，锌都可促进甲状激素合成[6]。另一项研究中，游离T3和总T3水平偏低，但rT3升高且锌中度缺乏的患者，口服补锌12个月后，患者血清游离T3和总T3水平恢复正常，rT3水平降低，TSH也恢复正常水平[7]。

维生素A缺乏与甲状腺功能障碍互为因果。一方面维生素A缺乏可能会改变甲状腺的结构，并破坏下丘脑-垂体-甲状腺（HPT）轴的信号网络[9-11]。反过来，甲减会阻碍β-胡萝卜素转化为有生物活性的维生素A[12]。对84名绝经前健康女性的研究中发现，每天补充25000 IU维生素A可以降低血中TSH水平，研究结论得出补充维生素A可以降低该人群亚临床甲减的风险[13]。

推荐人群  

Thyroid Nutrition适用于所有类型的甲减、亚临床甲减，以及桥本氏甲状腺炎患者。

*UGN产品符合FDA和美国联邦贸易委员会关于营养补充剂产品相关疾病声明的监管要求，产品不用于预防、诊断和治疗任何疾病。如患有任何疾病，请咨询专业人员。

建议用量

成人每天随餐服用2粒，或在专业人员的指导下服用。

参考文献

[1] Sharma AK, Basu I, Singh S. Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial. Journal of alternative and complementary medicine (New York, NY). 2018;24(3):243-248.

[2]Gannon JM, Forrest PE, Roy Chengappa KN. Subtle changes in thyroid indices during a placebo-controlled study of an extract of Withania somnifera in persons with bipolar disorder. Journal of Ayurveda and integrative medicine. 2014;5(4):241-245.

[3] Ventura M, Melo M, Carrilho F. Selenium and Thyroid Disease: From Pathophysiology to Treatment. International Journal of Endocrinology. 2017;2017:9.

[4] Wu Q, Rayman MP, Lv H, et al. Low Population Selenium Status Is Associated With Increased Prevalence of Thyroid Disease. J Clin Endocrinol Metab. 2015;100(11):4037-4047. 

[5]Severo JS, Morais JBS, de Freitas TEC, et al. The Role of Zinc in Thyroid Hormones Metabolism. International journal for vitamin and nutrition research Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung Journal international de vitaminologie et de nutrition. 2019;89(1-2):80-88.

[6]Mahmoodianfard S, Vafa M, Golgiri F, et al. Effects of Zinc and Selenium Supplementation on Thyroid Function in Overweight and Obese Hypothyroid Female Patients: A Randomized Double-Blind Controlled Trial. J Am Coll Nutr. 2015;34(5):391-399.

[7]Nishiyama S, Futagoishi-Suginohara Y, Matsukura M, et al. Zinc supplementation alters thyroid hormone metabolism in disabled patients with zinc deficiency. J Am Coll Nutr. 1994;13(1):62-67.

[8]Krysiak, R., Szkróbka, W., & Okopień, B. (2017). The Effect of Vitamin D on Thyroid AutoimmIUnity in Levothyroxine-Treated Women with Hashimoto's Thyroiditis and Normal Vitamin D Status. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 125(4), 229–233.

[9] Zimmermann MB. Interactions of vitamin A and iodine deficiencies: effects on the pituitary-thyroid axis. International journal for vitamin and nutrition research Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung Journal international de vitaminologie et de nutrition. 2007;77(3):236-240.

[10] Strum JM. Alterations within the rat thyroid gland during vitamin A deficiency. Am J Anat. 1979;156(2):169-182.

[11] Morley JE, Damassa DA, Gordon J, Pekary AE, Hershman JM. Thyroid function and vitamin A deficiency. Life Sci. 1978;22(21):1901-1905.

[12] Aktuna D, Buchinger W, Langsteger W, et al. [Beta-carotene, vitamin A and carrier proteins in thyroid diseases]. Acta medica Austriaca. 1993;20(1-2):17-20.

[13] Farhangi MA, Keshavarz SA, Eshraghian M, Ostadrahimi A, Saboor-Yaraghi AA. The effect of vitamin A supplementation on thyroid function in premenopausal women. J Am Coll Nutr. 2012;31(4):268-274.