铜-氧化学 Copper-Oxygen Chemistry

基本信息

Series:Organic Reactions

Format:Paperback / softback 768 pages

Publisher:John Wiley & Sons Inc

Imprint:John Wiley & Sons Inc

ISBN:9780470547878

Published:19 Mar 2010

Weight:1007g

Dimensions:229 x 155 (mm)

信息仅供参考，具体请以实物为准

书籍简介

涵盖了生物系统中由铜离子介导的氧化过程这一广泛扩展的主题

铜介导的生物氧化提供了一系列跨许多化学和制药学科的、具有根本重要性和潜在实用性的化学过程。Wiley 系列《化学和生物学中的反应中间体》的新一卷在铜/氧化学主题中分为三个逻辑领域——生物系统、理论和生物无机模型与应用——以探索生物圈的高度进化和高效的氧化转化，从而发现分子氧和铜离子之间新型的相互作用。《铜氧化学》以一个完整而全面的资源为特色，将各种主题统一起来，探讨了铜配位化学、合成有机化学和生物化学的基本方面，揭示了推动铜氧化学背后当前令人兴奋的研究工作的生物和化学方面。此外，铜氧化学：

·介绍了关于氧原子插入和碳碳键形成反应以及对映选择性氧化化学方面日益增多的文献

·从生物系统发展到光谱学和理论，再到生物无机模型和应用

·涵盖了多种反应类型，例如利用廉价、丰富且含能的 O2 分子的插入和脱氢反应

本书由杰出的作者和研究人员进行了全面介绍，他们正在塑造这一不断发展的领域的创新，这本有价值的参考书是生物无机化学家以及学术界和工业界的有机、合成和药物化学家的可读书籍。

Covers the vastly expanding subject of oxidative processes mediated by copper ions within biological systems

Copper-mediated biological oxidations offer a broad range of fundamentally important and potentially practical chemical processes that cross many chemical and pharmaceutical disciplines. This newest volume in the Wiley Series on Reactive Intermediates in Chemistry and Biology is divided into three logical areas within the topic of copper/oxygen chemistry— biological systems, theory, and bioinorganic models and applications—to explore the biosphere for its highly evolved and thus efficient oxidative transformations in the discovery of new types of interactions between molecular oxygen and copper ion. Featuring a diverse collection of subject matter unified in one complete and comprehensive resource, Copper-Oxygen Chemistry probes the fundamental aspects of copper coordination chemistry, synthetic organic chemistry, and biological chemistry to reveal both the biological and chemical aspects driving the current exciting research efforts behind copper-oxygen chemistry. In addition, Copper-Oxygen Chemistry:

Addresses the significantly increasing literature on oxygen-atom insertion and carbon-carbon bond-forming reactions as well as enantioselective oxidation chemistries

Progresses from biological systems to spectroscopy and theory, and onward to bioinorganic models and applications

Covers a wide array of reaction types such as insertion and dehydrogenation reactions that utilize the cheap, abundant, and energy-containing O2 molecule

With thorough coverage by prominent authors and researchers shaping innovations in this growing field, this valuable reference is essential reading for bioinorganic chemists, as well as organic, synthetic, and pharmaceutical chemists in academia and industry.

作者简介

Kenneth D. Karlin 是约翰霍普金斯大学的 Ira Remsen 化学教授。他的生物无机研究重点是与生物和环境过程相关的配位化学，涉及铜或血红素（卟啉-铁）复合物。Karlin 博士的主要方法涉及合成建模，即仿生化学。他是知名的 F. Albert Cotton 合成无机化学奖和 Sierra Nevada 杰出化学家奖的获得者，这两项奖项均于 2009 年颁发。

Shinobu Itoh 目前的研究重点是化学建模和生物系统中新型活性位点的应用。他曾是大阪大学的助理教授，在那里他研究了辅酶 PQQ 和辅因子 TTQ 的化学以及半乳糖氧化酶的模型化合物。1994 年，他晋升为大阪大学副教授，在那里他与 Shunichi Fukuzumi 教授合作进行铜-二氧化学研究。 1999年，他转任大阪市立大学教授，开始对血蓝蛋白和酪氨酸酶等双核铜蛋白进行生物学研究。2008年，他回到大阪大学，进一步将研究兴趣扩展到利用基因工程设计人工非血红素金属酶。

Kenneth D. Karlin is Ira Remsen Professor of Chemistry at Johns Hopkins University. His bioinorganic research focuses on coordination chemistry relevant to biological and environmental processes, involving copper or heme (porphyrin-iron) complexes. Dr. Karlin's main approach involves synthetic modeling, i.e., biomimetic chemistry. He is the winner of the prestigious F. Albert Cotton Award in Synthetic Inorganic Chemistry and the Sierra Nevada Distinguished Chemist Award, both awarded in 2009.

Shinobu Itoh focuses his current research on chemical modeling and application of novel active sites in biological systems. He was formerly an assistant professor at Osaka University, where he worked on the chemistry of coenzyme PQQ and cofactor TTQ as well as model compounds of galactose oxidase. In 1994, he was promoted to associate professor at Osaka University, where he collaborated with Professor Shunichi Fukuzumi in copper-dioxygen chemistry research. In 1999, he moved to Osaka City University as a full professor and started biological studies of dinuclear copper proteins, such as hemocyanin and tyrosinase. He returned to Osaka University in 2008 and further expanded his research interests to the design of artificial non-heme metalloenzymes using genetic engineering.

部分目录，仅供参考

Preface to Series vii

Introduction ix

Contributors xi

1 Insights into the Proposed Copper–Oxygen Intermediates that Regulate the Mechanism of Reactions Catalyzed by Dopamine b-Monooxygenase, Peptidylglycine a-Hydroxylating Monooxygenase, and Tyramine b-Monooxygenase 1

Robert L. Osborne and Judith P. Klinman

2 Copper Dioxygenases 23

Jozsef Kaizer, Jozsef Sandor Pap, and Gabor Speier

3 Amine Oxidase and Galactose Oxidase 53

Dalia Rokhsana, Eric M. Shepard, Doreen E. Brown, and David M. Dooley

4 Energy Conversion and Conservation by Cytochrome Oxidases 107

Angela Paulus and Simon de Vries

5 Multicopper Proteins 131

Takeshi Sakurai and Kunishige Kataoka

6 Structure and Reactivity of Copper–Oxygen Species Revealed by Competitive Oxygen-18 Isotope Effects 169

Justine P. Roth

7 Theoretical Aspects of Dioxygen Activation in Dicopper Enzymes 197

Kazunari Yoshizawa

8 Chemical Reactivity of Copper Active-Oxygen Complexes 225

Shinobu Itoh

9 Cytochrome c Oxidase and Models 283

Zakaria Halime and Kenneth D. Karlin

10 Supramolecular Copper Dioxygen Chemistry 321

Jean-Noel Rebilly and Olivia Reinaud

11 Organic Synthetic Methods Using Copper Oxygen Chemistry 361

Marisa C. Kozlowski

Index 445